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In many industrialized countries, non-alcoholic fatty liver
disease (NAFLD) is a very common liver disease, with an
estimated worldwide prevalence of nearly 25% [1]. A study
conducted in Netherlands documented about 22% of the
population are suffering from fatty liver [2]. According
to the Third National Health and Nutrition Examination
Survey performed in the United States, the prevalence was
19.0% [3]. In Taiwan, the prevalence was estimated to be
about 21%-43%, according to two cross-sectional studies
[4,5].
There is a close relationship between NAFLD, meta-
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