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Acute severe bleeding is a leading cause of death.1 Traumatic extracranial haemorrhage, often the consequence of road traffic crashes or violence, is responsible for more than two million deaths each year.2 Traumatic and spontaneous intracranial bleeding are common causes of death and disability.3 Severe surgical haemorrhage strongly predicts adverse patient outcomes and is associated with an increase in the odds of death………………………..

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32455-8/fulltext?elsca1=etoc

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