Introduction

In 2012, 1·82 million cases of lung cancer were diagnosed worldwide.1 Overall, up to 30% of patients with non-small cell lung cancer (NSCLC) will present with or develop brain metastases subsequently;2, 3 for patients with stage 3 disease treated with radical intent who achieve a partial or complete radiological response, the risk of subsequently developing brain metastases is 50%.4, 5 Lung cancer is the most common cause of brain metastases, constituting 50–65% of patients within published epidemiological studies and brain radiotherapy trials.6, 7, 8, 9, 10, 11 Historically, survival rates after…..continue reading     http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30825-X/fulltext?elsca1=etoc

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